India’s First National-level Paired (Swap) Kidney Donation Registry

STAR Hospitals, Kidney Transplant Program

Dr. G. Jyothsna
Star Hospitals, Hyderabad Introduces India’s First National-level
Paired (Swap) Kidney Donation Registry
India’s kidney donor shortage is worrying, in a year over 2,00,000 patients need a kidney transplant in India. But, only roughly 8,000 to 12,000 kidney transplants are happening. Diabetes, malnutrition, overcrowding, and poor sanitation all contribute to the high prevalence of Chronic Kidney disease (CKD) in India, which affects approximately 17% of the population. CKD frequently progresses to end-stage renal disease (ESRD).

Inspite of best treatment options only 3% to 5% of patients undergoing Kidney Transplantation now. The main reason is the lack of donors, as per the National Organ & Tissue Transplant Act only family donors can donate the kidney to their relatives. Inspite of some situation where donors are available within the family but their blood groups are not matching this is the reason for 40% of the donor rejections. For this set of patients, the available option is ABO Incompatible Kidney Transplant & Paired (Swap) Kidney Exchange.

With Paired (Swap) Kidney Exchange we can increase the donor poll from 5% to 40%. But, now in India only few numbers of Paired (Swap) Kidney Exchange are going on compared to western population or other developed countries where 30% to 40% of transplants are because of Paired (Swap) Kidney Exchange. In India in the last few years very few Paired (Swap) Kidney Exchanges have happened, this is because of lack of awareness.

Widespread awareness amongst the community is that for a Kidney Transplantation blood group matching is a must. But, in case of not matching there are two solutions ABO Incompatible & Paired (Swap) Kidney Transplantation which 90% of the common people are not aware of.

To improve that awareness if they have family donors and not matched, they decide that donor is not available. Unless they are aware of ABO incompletable or Paired (Swap) Kidney Transplantation, where blood group match is not a must.
Star Hospitals has achieved remarkable success in performing Swap Kidney Transplants and ABO Incompatible Kidney Transplants, revolutionizing the landscape of organ transplantation. Kidney Swap Transplants involve exchanging kidneys among incompatible donor-recipient pairs, facilitating life-saving matches that might otherwise be unattainable. This innovative approach significantly expands the pool of potential donors, providing a solution for patients facing compatibility challenges. Star also excels in ABO Incompatible Kidney Transplants, where the transplant occurs between a donor and recipient with different blood types. This pioneering technique transcends traditional barriers, allowing patients to receive kidneys from donors who may not share the same blood type. These advanced procedures represent a beacon of hope for individuals in need, reducing dependency on cadaver donors and offering a transformative solution to the pressing challenges of kidney failure.

To facilitate seamless registration and participation, Star Hospitals has launched a dedicated web page. This user-friendly interface will enable individuals to register for the Kidney Paired Donation Registry, providing a centralized hub for potential donors and recipients to connect. The web page will also serve as an informative resource, guiding users through the process and educating them about the benefits of paired donations.

The hospital believes that this online platform will not only streamline the registration process but also serve as a hub for education and awareness regarding kidney transplants and the options available to patients.

What is paired kidney exchange
When someone wants to give a kidney to a family member but they don't match, a kidney swap can help. This may be termed as 'Paired Kidney Exchange' or 'Swap Kidney Transplant'. In a swap, two families exchange kidneys so that both recipients get a match. It's like teamwork where two donors give kidneys to two different people at the same time. This swap is needed when the blood types don't match within a family. It's a way for families facing this challenge to still help each other. This process creates a chain of kidney exchanges, making sure that everyone finds the right match and gets the kidney they need.

How does it work:
Assume there is a PAIR 1 with Recipient 1 in blood group A and Donor 1 in blood group B, as well as a PAIR 2 with Recipient 2 in blood group B and Donor 2 in blood group A.
 In a two-pair exchange, Donor 1 with blood group B can donate to Recipient 2 with blood group B, while Donor 2 with blood group A can contribute to Recipient 1 with blood group A. This results in two transplant surgeries occurring simultaneously.
Similarly, several paired exchanges can be undertaken, which is known as a Domino Kidney Paired Exchange. Aside from ABO incompatible transplants, paired kidney exchange can be considered in HLA incompatible donor recipient pairs, in which the donor and recipient share the same blood group but the recipient has anti-HLA antibodies against the donor tissue, resulting in a positive tissue cross match, and transplantation in such donor recipient pairs is usually not recommended.
When to consider Paired Kidney Exchange
It should be considered for all transplant candidates who have a living donor who is medically fit but unable to give a kidney to the intended recipient due to ABO or HLA incompatibility. It is also worth considering whether a kidney switch allows the patient to have a better matched transplant in terms of HLA, kidney size, and donor age.
Kidney Paired Donation Registry
It is a groundbreaking initiative that empowers individuals to actively participate in their search for a compatible kidney donor. Through this registry, potential donors and recipients are intricately connected, enabling paired donations and eliminating the often-lengthy wait for a cadaver donor. This not only expedites the transplantation process but also significantly broadens the pool of potential matches, increasing the chances of successful transplantation.

A free platform where individuals can seamlessly connect with potential kidney donors and recipients. This groundbreaking registry empowers users by intricately linking donors with recipients, facilitating paired donations and eliminating the often-protracted wait for a cadaver donor. By leveraging this innovative platform, individuals can expedite the transplantation process and dramatically broaden their pool of potential matches, significantly enhancing the prospects of successful transplantation. This revolutionary approach not only accelerates access to life-saving treatments but also fosters a supportive community where individuals can find hope, solidarity, and renewed health.

For Free Registration on Star Hospitals Paired (Swap) Kidney Donation Registry:
For more details please contact:  07969250191

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